Detailed view for Tb927.8.1750

Basic information

TDR Targets ID: 16243
Trypanosoma brucei, Fe-S cluster assembly protein DRE2
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.2032 | Length (AA): 124 | MW (Da): 13129 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05093   Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0051536   iron-sulfur cluster binding  
GO:0016226   iron-sulfur cluster assembly  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_128282)

Species Accession Gene Product
Arabidopsis thaliana AT5G18400   anamorsin homolog
Babesia bovis BBOV_I003760   hypothetical protein
Brugia malayi Bm1_48140   Hypothetical 25.6 kDa protein T20B12.7 in chromosome III
Candida albicans CaO19.2825   contains a match to DUF689
Candida albicans CaO19.10342   contains a match to DUF689
Candida albicans CaO19.10343   similar to N terminus of S. cerevisiae YKR071C
Caenorhabditis elegans CELE_T20B12.7   Protein T20B12.7
Cryptosporidium hominis Chro.60473   hypothetical protein
Cryptosporidium parvum cgd6_4130   conserved hypothetical protein
Dictyostelium discoideum DDB_G0285251   hypothetical protein
Drosophila melanogaster Dmel_CG4180   CIAPIN1 ortholog
Echinococcus granulosus EgrG_000621600   Anamorsin
Echinococcus multilocularis EmuJ_000621600   Anamorsin
Homo sapiens ENSG00000005194   cytokine induced apoptosis inhibitor 1
Leishmania braziliensis LbrM.07.0230   hypothetical protein, conserved
Leishmania donovani LdBPK_070390.1   Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis, putative
Leishmania infantum LinJ.07.0390   hypothetical protein, conserved
Leishmania major LmjF.07.0230   hypothetical protein, conserved
Leishmania mexicana LmxM.07.0230   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_08430   hypothetical protein
Mus musculus ENSMUSG00000031781   cytokine induced apoptosis inhibitor 1
Neospora caninum NCLIV_059410   hypothetical protein
Oryza sativa 4337380   Os04g0674400
Oryza sativa 9266719   Os04g0682050
Onchocerca volvulus OVOC1117   Anamorsin homolog
Plasmodium berghei PBANKA_0706000   Fe-S cluster assembly protein DRE2, putative
Plasmodium falciparum PF3D7_0824600   Fe-S cluster assembly protein DRE2, putative
Plasmodium knowlesi PKNH_1318600   Fe-S cluster assembly protein DRE2, putative
Plasmodium vivax PVX_089130   Fe-S cluster assembly protein DRE2, putative
Plasmodium yoelii PY03124   hypothetical protein
Saccharomyces cerevisiae YKR071C   Dre2p
Schistosoma japonicum Sjp_0091310   IPR000005,Helix-turn-helix, AraC type,domain-containing
Schistosoma japonicum Sjp_0069250   Anamorsin, putative
Schistosoma mansoni Smp_146230   hypothetical protein
Schistosoma mansoni Smp_006210   hypothetical protein
Schmidtea mediterranea mk4.003915.00   Anamorsin homolog
Trypanosoma brucei gambiense Tbg972.8.1370   hypothetical protein, conserved
Trypanosoma brucei Tb927.8.1750   Fe-S cluster assembly protein DRE2
Trypanosoma congolense TcIL3000_8_1660   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511393.79   Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis, putative
Trypanosoma cruzi TcCLB.505071.119   Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis, putative
Toxoplasma gondii TGME49_216900   cytokine induced apoptosis inhibitor 1 family protein
Theileria parva TP01_0461   hypothetical protein, conserved

Essentiality

Tb927.8.1750 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.1750 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.1750 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.1750 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.1750 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T20B12.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_T20B12.7 Caenorhabditis elegans larval arrest wormbase
CELE_T20B12.7 Caenorhabditis elegans slow growth wormbase
YKR071C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0706000 Plasmodium berghei Essential plasmo
TGME49_216900 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Tb927.8.1750 (Trypanosoma brucei), Fe-S cluster assembly protein DRE2
Title for this comment
Comment